Residual γH2AX foci as an indication of lethal DNA lesions
نویسندگان
چکیده
منابع مشابه
γH2AX Foci Form Preferentially in Euchromatin after Ionising-Radiation
BACKGROUND The histone variant histone H2A.X comprises up to 25% of the H2A complement in mammalian cells. It is rapidly phosphorylated following exposure of cells to double-strand break (DSB) inducing agents such as ionising radiation. Within minutes of DSB generation, H2AX molecules are phosphorylated in large chromatin domains flanking DNA double-strand breaks (DSBs); these domains can be ob...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2010
ISSN: 1471-2407
DOI: 10.1186/1471-2407-10-4